Open AccessStructure and function of M ycobacterium tuberculosis meso ‐diaminopimelic acid ( DAP ) biosynthetic enzymes
Author(s) -
Usha Veeraraghavan,
Lloyd Adrian J.,
Lovering Andrew L.,
Besra Gurdyal S.
Publication year - 2012
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2012.02527.x
Subject(s) - diaminopimelic acid , enzyme , mycobacterium tuberculosis , microbiology and biotechnology , bacteria , biology , biochemistry , function (biology) , tuberculosis , actinobacteria , mycobacterium , biosynthesis , peptidoglycan , genetics , medicine , 16s ribosomal rna , pathology
Because of an increased emergence of resistance to current antitubercular drugs, there is a need for new antitubercular agents directed against novel targets. Diaminopimelic acid ( DAP ) biosynthetic enzymes are unique to bacteria and are absent in mammals and provide a rich source of essential targets for antitubercular chemotherapy. Herein, we review the structure and function of the mycobacterial DAP biosynthetic enzymes.