Open AccessStress signalling to fungal stress‐activated protein kinase pathways
Author(s) -
Smith Deborah A.,
Morgan Brian A.,
Quinn Janet
Publication year - 2010
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2010.01937.x
Subject(s) - schizosaccharomyces pombe , microbiology and biotechnology , biology , signal transduction , protein kinase a , saccharomyces cerevisiae , kinase , candida albicans , phosphorylation , yeast , signalling pathways , schizosaccharomyces , biochemistry , genetics
The ability of microorganisms to survive and thrive within hostile environments depends on rapid and robust stress responses. Stress‐activated protein kinase (SAPK) pathways are important stress‐signalling modules found in all eukaryotes, including eukaryotic microorganisms such as fungi. These pathways consist of a SAPK that is activated by phosphorylation through a kinase cascade, and once activated, the SAPK phosphorylates a range of cytoplasmic and nuclear target substrates, which determine the appropriate response. However, despite their conservation in fungi, mechanisms that have evolved to relay stress signals to the SAPK module in different fungi have diverged significantly. Here, we present an overview of the diverse strategies used in the model yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe , and the pathogenic fungus Candida albicans , to sense and transduce stress signals to their respective SAPKs.