Open AccessBicyclic compounds repress membrane vesicle production and Pseudomonas quinolone signal synthesis in Pseudomonas aeruginosa
Author(s) -
Tashiro Yosuke,
Toyofuku Masanori,
NakajimaKambe Toshiaki,
Uchiyama Hiroo,
Nomura Nobuhiko
Publication year - 2010
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2010.01897.x
Subject(s) - pseudomonas aeruginosa , quorum sensing , virulence , pseudomonadales , pseudomonas , microbiology and biotechnology , bicyclic molecule , biology , pseudomonadaceae , quinolone , downregulation and upregulation , chemistry , bacteria , gene , biochemistry , stereochemistry , genetics , antibiotics
Pseudomonas aeruginosa secretes membrane vesicles (MVs) that deliver several virulence factors as a cargo. We found that indole and its derivative compounds, including 4‐hydroxyindole, 5‐hydroxyindole, 6‐hydroxyindole and isatin, repress MV production significantly. These compounds also repressed the synthesis of Pseudomonas quinolone signal (PQS), which is one of the quorum‐sensing signals that upregulate virulence gene expression and positively control MV production. Moreover, we showed that other bicyclic compounds, including 1‐naphthol, 2‐naphthol, 2,3‐dihydroxynaphthalene, 1‐aminonaphthalene and 8‐quinolinol, significantly repress MV production and PQS synthesis. In conclusion, we provide new information about the chemical structures that inhibit P. aeruginosa virulence.