Open AccessTwo different mechanisms of ampicillin resistance operating in strains of Vibrio cholerae O1 independent of resistance genes
Author(s) -
Nguyen Dong Tu,
Ngo Tuan Cuong,
Tran Huy Hoang,
Nguyen Thi Phuong Lan,
Nguyen Binh Minh,
Morita Kouichi,
Ehara Masahiko
Publication year - 2009
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2009.01693.x
Subject(s) - vibrio cholerae , strain (injury) , microbiology and biotechnology , biology , ampicillin , gene , amp resistance , bacteria , vibrionaceae , genetics , antibiotics , anatomy
Autoagglutinable strains of Vibrio cholerae O1 (seven nonfimbriate strains and one fimbriate strain) were transformed to obtain resistance to ampicillin. Two distinct mechanisms were found in these strains. One was operating in nonfimbriate strains by reducing OmpU protein production and the other was operating in a fimbriate strain (Bgd17) by newly overproducing cpxP protein. The twitching motility in the fimbriate Bgd17 strain disappeared depending on the production of cpxP protein, suggesting that fimbriation of V. cholerae O1 is controlled by a two‐component signal transduction system.