Open AccessOxyR is involved in coordinate regulation of expression of fimA and sod genes in Porphyromonas gingivalis
Author(s) -
Wu Jie,
Lin Xinghua,
Xie Hua
Publication year - 2008
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2008.01116.x
Subject(s) - porphyromonas gingivalis , fimbria , gene expression , gene , virulence , regulation of gene expression , promoter , biology , transcription (linguistics) , transcription factor , superoxide dismutase , microbiology and biotechnology , sigma factor , oxidative stress , genetics , bacteria , biochemistry , philosophy , linguistics
Survival of Porphyromonas gingivalis in the constantly changing oral environment depends on its ability to alter gene expression. We demonstrate here that P. gingivalis activates superoxide dismutase expression in response to oxidative stress and represses expression of FimA, a subunit of major fimbriae. Coordinated expression of fimA and sod is regulated by the redox‐sensing transcription factor OxyR. Mutations in the oxyR gene result in a decreased expression of sod and in an elevated expression of fimA . In addition, we provide evidence that regulation of expression of fimA and sod by OxyR is mediated by direct interaction of OxyR and the promoters of these two genes. These results suggest that OxyR plays an important role in regulation of expression of virulence genes in P. gingivalis .