Open AccessChemosensitization of fungal pathogens to antimicrobial agents using benzo analogs
Author(s) -
Kim Jong H.,
Mahoney Noreen,
Chan Kathleen L.,
Molyneux Russell J.,
May Gregory S.,
Campbell Bruce C.
Publication year - 2008
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2008.01072.x
Subject(s) - superoxide dismutase , oxidative stress , glutathione reductase , chemistry , biochemistry , antimicrobial , glutathione , antifungal , microbiology and biotechnology , biology , enzyme , glutathione peroxidase
Activities of conventional antifungal agents, fludioxonil, strobilurin and antimycin A, which target the oxidative and osmotic stress response systems, were elevated by coapplication of certain benzo analogs (aldehydes and acids). Fungal tolerance to 2,3‐dihydroxybenzaldehyde or 2,3‐dihydroxybenzoic acid was found to rely upon mitochondrial superoxide dismutase ( SOD2 ) or glutathione reductase ( GLR1 ), genes regulated by the HOG1 signaling pathway, respectively. Thus, certain benzo analogs can be effective at targeting cellular oxidative stress response systems. The ability of these compounds to chemosensitize fungi for improved control with conventional antifungal agents is discussed.