Open AccessWild‐type Leishmania donovani promastigotes block maturation, increase integrin expression and inhibit detachment of human monocyte‐derived dendritic cells – the influence of phosphoglycans
Author(s) -
Tejle Katarina,
Lindroth Margaretha,
Magnusson KarlEric,
Rasmusson Birgitta
Publication year - 2008
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2007.01013.x
Subject(s) - leishmania donovani , leishmania , monocyte , biology , immune system , dendritic cell , microbiology and biotechnology , antigen , immunology , parasite hosting , leishmaniasis , visceral leishmaniasis , world wide web , computer science
The protective immune response against the parasite, including the role of dendritic cells (DC) in the course of infection, plays a fundamental role. This study shows that wild‐type (WT) Leishmania promastigotes and specifically the phosphoglycans family of virulence‐associated antigens inhibit human monocyte‐derived dendritic cells (MoDC) maturation and detachment to distinct surfaces. Immature phagocytosis of Leishmania donovani promastigotes by immature MoDC results in the increased expression of CD11b and CD51, and inhibition of cell detachment to distinct surfaces, which was dependent on the presence of phosphoglycans. These findings demonstrate that phosphoglycans of WT L. donovani might also inhibit human DC migration to lymphoid organs.