Open AccessCoronin‐1A epigenomics governs mycobacterial persistence in tuberculosis
Author(s) -
Kaul Deepak
Publication year - 2008
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2007.00976.x
Subject(s) - tuberculosis , mycobacterium tuberculosis , epigenomics , biology , microbiology and biotechnology , computational biology , medicine , gene , genetics , gene expression , pathology , dna methylation
The lack of innovative therapies and the emergence of multi‐drug‐resistant pathogens emphasize the urgency of finding new approaches to fighting intracellular pathogens in general and Mycobacterium tuberculosis in particular, especially given the fact that tuberculosis is widely recognized as a major health problem worldwide. This review describes how host phagocytic cellular Coronin‐1A gene epigenomics can be used to understand the subversive strategy adopted by M. tuberculosis to avoid encounter with the harsh environment within the phagocytic vacuole, and how it may provide a novel approach for the prevention and treatment of tuberculosis.