Open AccessSusceptibility of human enterotoxigenic Escherichia coli isolates to growth inhibition by porcine intestinal epithelial cells
Author(s) -
Brown Eric A.,
Kaushik Radhey S.,
Hardwidge Philip R.
Publication year - 2007
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2007.00814.x
Subject(s) - enterotoxigenic escherichia coli , microbiology and biotechnology , escherichia coli , biology , incubation , cell culture , enterobacteriaceae , epithelium , escherichia , bacteria , enterotoxin , biochemistry , gene , genetics
Growth of human, but not porcine enterotoxigenic Escherichia coli (ETEC) isolates is inhibited during incubation with porcine intestinal epithelial cells and by a constitutively produced factor(s) present in unstimulated cell supernatants. The inhibitory factor(s) is heat stable, not produced by serum‐starved cells, and is present in a diverse number of cultured epithelial cell lines of animal, but not of human origin. Susceptibility to porcine intestinal epithelial cells appears to be restricted to ETEC and not E. coli O157:H7 disease isolates.