Open AccessInhibition of infection of the rice blast fungus by halisulfate 1, an isocitrate lyase inhibitor
Author(s) -
Shin DongSun,
Lee TaeHoon,
Lee HyiSeung,
Shin Jongheon,
Oh KiBong
Publication year - 2007
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2007.00733.x
Subject(s) - isocitrate lyase , fungus , chemistry , lyase , microbiology and biotechnology , enzyme , biology , biochemistry , botany , glyoxylate cycle
Halisulfate 1, a sesterterpene sulfate and an isocitrate lyase (ICL) inhibitor that is isolated from tropical sponge Hippospongia spp., reduces both appressorium formation and infection of rice plants by the fungus Magnaporthe grisea . Rice plants infected with wild‐type M. grisea Guy 11 exhibited significantly lower disease severity after halisulfate 1 treatment than without, and the treatment effect was comparable to the behavior of the Δ icl knockout mutant I‐10. The protection observed upon applying halisulfate 1 to rice plants suggests that the ICL inhibitor may be a promising candidate for crop protection, particularly to protect rice plants against M. grisea .