Open AccessA universal stress protein of Porphyromonas gingivalis is involved in stress responses and biofilm formation
Author(s) -
Chen Wen,
Honma Kiyonobu,
Sharma Ashu,
Kuramitsu Howard K.
Publication year - 2006
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2006.00426.x
Subject(s) - porphyromonas gingivalis , biofilm , microbiology and biotechnology , mutant , strain (injury) , chronic periodontitis , chemistry , periodontitis , periodontal disease , gene , biology , bacteria , genetics , medicine , biochemistry , dentistry , anatomy
Porphyromonas gingivalis is recognized as one of the major periodontal pathogens in subgingival plaque, which is implicated in the progression of chronic periodontal disease. We analyzed the role of upsA in P. gingivalis 381 and its uspA ‐deficient mutant CW301 under various stress conditions. In general, the uspA mutant was less tolerant to a variety of environmental stresses relative to the parental strain. In addition, gene expression of uspA is upregulated during biofilm formation. Biofilm formation of the uspA mutant was also less than that of strain 381. In conclusion, the uspA gene affecting the stress responses of P. gingivalis is required for optimal biofilm formation.