Open AccessInheritance and state switching of genetic toggle switch in different culture growth phases
Author(s) -
Stupak E.E.,
Stupak I.V.
Publication year - 2006
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2006.00194.x
Subject(s) - bistability , inheritance (genetic algorithm) , biological system , phenotype , biology , population , genetics , gene , genetic network , control theory (sociology) , computer science , physics , artificial intelligence , optoelectronics , demography , control (management) , sociology
Abstract Using the gene engineering methods, one can construct simple artificial gene networks with two stable functioning regimes (bistable genetic systems). Such genetic systems make it possible for cells with identical genotype to inherit two alternative phenotypes. The toggle switch is just one of the types of bistable genetic systems. In this work, we investigate the inheritance and switching of toggle switch functioning regimes in the cells at different culture growth phases. It is shown that during transition into the stationary growth phase the inheritance of stable states is disturbed and variations in the toggle‐switching rate are more possible in different cells. Also, simultaneous expression of two genes of the system has been experimentally modelled. According to our results, the culture growth phase in this period determinates later on the ratio between cell phenotypes in a population.