Open AccessLeishmania donovani cyclin 1 (LdCyc1) forms a complex with cell cycle kinase subunit CRK3 (LdCRK3) and is possibly involved in S‐phase‐related activities
Author(s) -
Banerjee Sampali,
Sen Abhik,
Das Pradeep,
Saha Partha
Publication year - 2006
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2006.00105.x
Subject(s) - leishmania donovani , cyclin dependent kinase , cell cycle , biology , microbiology and biotechnology , leishmania , cyclin , protein subunit , cyclin dependent kinase 2 , kinase , protein kinase a , biochemistry , cell , parasite hosting , gene , genetics , leishmaniasis , visceral leishmaniasis , world wide web , computer science
Expression of Leishmania donovani cyclin 1 (LdCyc1) mRNA during the cell cycle of promastigotes is S‐phase specific. Here, we show that the LdCyc1 protein is periodically expressed and the activity of its associated kinase varies during the cell cycle in line with its expression pattern. In addition, we have shown that LdCRK3, homologous to CRK3 from L. mexicana , is the cognate Cdk partner of LdCyc1 and that the activity of the complex is inhibited specifically by heat stable factor(s) from the parasite.