Open AccessHomology effects in Neurospora crassa
Author(s) -
Catalanotto Caterina,
Nolan Tony,
Cogoni Carlo
Publication year - 2006
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2005.00037.x
Subject(s) - neurospora crassa , biology , crassa , genetics , transposable element , genome , gene , neurospora , organism , gene silencing , homology (biology) , nucleic acid , model organism , computational biology , mutant
It has become clear in the past few years that eukaryotic organisms possess different genetic systems to counter viruses, transposons and other repeated elements such as transgenes that could otherwise accumulate in the genome. In addition to serving as a model organism for genetic, biochemical and molecular studies, Neurospora crassa has proved to be a paradigm for the study of gene‐silencing mechanisms. Indeed, its genome can be protected from expansion of selfish nucleic acids by a variety of mechanisms that inactivate duplicated sequences. Studies of these mechanisms have made a fundamental contribution to the understanding of the gene‐silencing field.