Open AccessDeoT, a DeoR‐type transcriptional regulator of multiple target genes
Author(s) -
ElgrablyWeiss Maya,
SchlosserSilverman Eliana,
Rosenshine Ilan,
Altuvia Shoshy
Publication year - 2006
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2005.00020.x
Subject(s) - gene , open reading frame , biology , transcriptional regulation , genetics , regulator , regulation of gene expression , transcription (linguistics) , transcription factor , promoter , gene expression , peptide sequence , linguistics , philosophy
Abstract In this study, we investigated the genetic organization and function of Escherichia coli yciT , a gene predicted by computational methods to belong to the DeoR‐type family of transcriptional regulators. We show that transcription of yciT (here denoted deoT for deoR ‐Type) initiates from a promoter located upstream of a putative open reading frame (denoted deoL for deoT Leader). We also show that DeoT acts as a global regulator, repressing the expression of a number of genes involved in a variety of metabolic pathways including transport of maltose, fatty acid β‐oxidation and peptide degradation.