Open AccessCharacterization of extended‐spectrum‐β‐lactamase (CTX‐M‐15)‐producing strains of Salmonella enterica isolated in France and Senegal
Author(s) -
Weill FrançoisXavier,
PerrierGrosClaude JeanDavid,
Demartin Marie,
Coignard Sophie,
Grimont Patrick A.D.
Publication year - 2004
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2004.tb09776.x
Subject(s) - salmonella enterica , microbiology and biotechnology , serotype , ribotyping , salmonella , biology , sulfamethoxazole , pulsed field gel electrophoresis , tetracycline , ampicillin , plasmid , trimethoprim , antibiotics , virology , multiple drug resistance , polymerase chain reaction , bacteria , gene , genotype , genetics
Three clinical isolates of Salmonella enterica recovered between 2000 and 2003 in France and Senegal were found to produce extended‐spectrum β‐lactamase CTX‐M‐15. The two isolates from Senegal were recovered from stool of a hospitalized patient with gastroenteritis in 2000 and from an urine specimen of an out‐patient with urinary tract infection in 2001. These S. enterica isolates belonged to serotype Kentucky and were clonally related as determined by pulsed‐field gel electrophoresis and automated ribotyping. The third isolate of serotype Typhimurium was recovered from a patient hospitalized in France for an acute gastroenteritis acquired in Lebanon. The bla CTX‐M‐15 gene was located on two different transferable plasmids, one of which also carried bla TEM‐1 , bla OXA‐30 , aminoglycoside‐, tetracycline‐, and sulfamethoxazole‐trimethoprim resistance genes. IS Ecp1 element was found to be located upstream of bla CTX‐M‐15 in the same position as reported previously in CTX‐M‐15‐producing Escherichia coli from India and Turkey. This is the first report of bla CTX‐M‐15 in the genus Salmonella .