Open AccessIdentification of a promoter motif regulating the major DNA damage response mechanism of Mycobacterium tuberculosis
Author(s) -
Gamulin Vera,
Cetkovic Helena,
Ahel Ivan
Publication year - 2004
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2004.tb09737.x
Subject(s) - repressor lexa , sos response , biology , dna repair , dna damage , dna , gene , genetics , homologous recombination , promoter , microbiology and biotechnology , repressor , transcription factor , gene expression
The principal response of many bacteria to DNA damage is mediated by a mechanism dependent on the LexA and RecA proteins. However, Mycobacterium tuberculosis was recently reported to regulate a majority of DNA repair genes independently of RecA and LexA, suggesting that an unknown RecA/LexA‐independent mechanism controls the major DNA damage response pathway in this organism. Here we have identified a motif tTGTCRgtg‐8nt‐TAnnnT that defines a novel RecA/LexA‐independent promoter (RecA‐NDp) of M. tuberculosis . Furthermore, we show that the RecA‐NDp type of promoter precedes DNA repair genes in other Actinomycetales.