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Plasmid‐mediated florfenicol and ceftriaxone resistance encoded by the floR and bla CMY‐2 genes in Salmonella enterica serovars Typhimurium and Newport isolated in the United States
Author(s) -
Doublet Benoît,
Carattoli Alessandra,
Whichard Jean M,
White David G,
Baucheron Sylvie,
ChaslusDancla Elisabeth,
Cloeckaert Axel
Publication year - 2004
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2004.tb09496.x
Subject(s) - microbiology and biotechnology , salmonella enterica , plasmid , biology , salmonella , florfenicol , tetracycline , multiple drug resistance , antibiotic resistance , escherichia coli , gene , drug resistance , genetics , antibiotics , bacteria
Multidrug resistance plasmids carrying the bla CMY‐2 gene have been identified in Salmonella enterica serovars Typhimurium and Newport from the United States. This gene confers decreased susceptibility to ceftriaxone, and is most often found in strains with concomitant resistance to ampicillin, chloramphenicol, streptomycin, sulfamethoxazole and tetracycline. The bla CMY‐2 ‐carrying plasmids studied here were shown to also carry the florfenicol resistance gene, floR , on a genetic structure previously identified in Escherichia coli plasmids in Europe. These data indicate that the use of different antimicrobial agents, including phenicols, may serve to maintain multidrug resistance plasmids on which extended‐spectrum cephalosporin resistance determinants co‐exist with other resistance genes in Salmonella .

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