Open AccessMobilization of the Vibrio pathogenicity island between Vibrio cholerae isolates mediated by CP‐T1 generalized transduction
Author(s) -
O'Shea Yvonne A,
Boyd E.Fidelma
Publication year - 2002
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2002.tb11339.x
Subject(s) - vibrio cholerae , pathogenicity island , virulence , microbiology and biotechnology , cholera toxin , biology , vibrio , pilus , transduction (biophysics) , cholera , gene , toxin , vibrionaceae , bacteria , genetics , biochemistry
Pathogenicity islands are large chromosomal regions encoding virulence genes that were acquired by horizontal gene transfer and are found in a wide range of pathogenic bacteria. In toxigenic Vibrio cholerae isolates the receptor for the cholera toxin encoding filamentous phage CTXφ, the toxin‐coregulated pilus, is part of the Vibrio pathogenicity island (VPI). In this paper, we show that the VPI can be transferred between O1 serogroup strains, the predominant cause of epidemic cholera, via a generalized transducing phage CP‐T1.