Open AccessA protein‐farnesyl transferase inhibitor interferes with the serum‐induced conversion of Candida albicans from a cellular yeast form to a filamentous form
Author(s) -
McGeady Paul,
Logan David A,
Wansley Daniel L
Publication year - 2002
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2002.tb11283.x
Subject(s) - candida albicans , yeast , biology , corpus albicans , microbiology and biotechnology , transferase , biochemistry , enzyme
A commercially available, cell permeable, protein‐farnesyl transferase inhibitor interfered with the serum‐induced morphological change in Candida albicans from a cellular yeast form to a filamentous form. The inhibitor has a negligible effect on the growth of C. albicans cells in the cellular yeast form, at the levels used to interfere with the morphological change. Conversion of C. albicans from the yeast form to filamentous form is associated with pathogenicity and hence protein‐farnesyl transferase inhibitors are potentially of therapeutic value against C. albicans infection.