Open AccessAbrB is a regulator of the σ W regulon in Bacillus subtilis
Author(s) -
Qian Qiang,
Lee Chien Y,
Helmann John D,
Strauch Mark A
Publication year - 2002
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2002.tb11228.x
Subject(s) - regulon , bacillus subtilis , sigma factor , regulator , psychological repression , promoter , operon , genetics , biology , sigma , gene , bacillaceae , regulation of gene expression , bacteria , escherichia coli , gene expression , physics , quantum mechanics
The Bacillus subtilis global regulator AbrB was found to negatively control expression of sigW and genes of the σ W regulon. AbrB bound to DNA regions in the autoregulatory sigW promoter and to some, but not all, of the other σ W ‐dependent promoters in B. subtilis . Defects in antibiotic resistance properties caused by spo0A mutations are at least partially correlated with AbrB repression of the σ W regulon.