Open AccessCharacterization of the Aspergillus nidulans 14‐3–3 homologue, ArtA
Author(s) -
Kraus Peter R.,
Hofmann Amy F.,
Harris Steven D.
Publication year - 2002
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2002.tb11160.x
Subject(s) - aspergillus nidulans , microbiology and biotechnology , morphogenesis , biology , hypha , function (biology) , cell cycle protein , genetics , gene , cell cycle , mutant
The 14‐3–3 family of proteins function as small adaptors that facilitate a diverse array of cellular processes by mediating specific protein interactions. One such process is the DNA damage checkpoint, where these proteins prevent inappropriate activation of cyclin‐dependent kinases. The filamentous fungus Aspergillus nidulans possesses a highly conserved 14‐3–3 homologue ( artA ) that may function in an analogous manner to prevent septum formation. However, instead of blocking septation, over‐expression of artA causes a severe delay in the polarization of conidiospores. This observation suggests that these proteins play an important role in hyphal morphogenesis.