Open AccessRecurrent intragenomic recombination leading to sequence homogenization during the evolution of the lipoyl‐binding domain
Author(s) -
Omelchenko Marina V.,
Makarova Kira S.,
Koonin Eugene V.
Publication year - 2002
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2002.tb11140.x
Subject(s) - biology , protein subunit , homogenization (climate) , genetics , binding domain , recombination , phylogenetic tree , computational biology , binding site , gene , biodiversity , ecology
The lipoyl‐binding domain is often present, in one or several copies, in the E2 subunit and, less often, in the E1 and E3 subunits of 2‐oxo acid dehydrogenase complexes. Phylogenetic analysis shows evidence of multiple, independent intragenomic recombination events between different versions of the lipoyl‐binding domain in various bacteria and eukaryotic mitochondria, leading to homogenization of the sequences of the lipoyl‐binding domain within the same enzymatic complex in several bacterial lineages. This appears to be the first case of sequence homogenization at the level of an individual domain in prokaryotes.