Open AccessClonality structure in Candida dubliniensis
Author(s) -
Badoc C,
De Meeûs T,
Bertout S,
Odds F.C.,
Mallié M,
Bastide J.M
Publication year - 2002
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2002.tb11139.x
Subject(s) - candida dubliniensis , biology , genetics , genotype , heterozygote advantage , population , population genetics , linkage (software) , molecular epidemiology , candida albicans , gene , corpus albicans , medicine , environmental health
Multilocus enzyme electrophoresis was performed on 76 European strains of Candida dubliniensis . Ten of the 20 enzyme‐encoding loci were polymorphic, giving rise to 10 electrophoretic types within the sample studied. Investigation of the population genetics of a subset of 36 strains from HIV‐infected patients in London showed the existence of strong heterozygote deficits and excesses associated with significant linkage disequilibria between pairs of loci. These findings, together with the predominance of multilocus genotypes, strongly suggest that C. dubliniensis is mainly (if not totally) clonal. Analysis of genotypes of a larger number of strains should confirm this conclusion and improve our understanding of the epidemiology of this pathogen.