Open AccessAntrodia camphorata polysaccharides exhibit anti‐hepatitis B virus effects
Author(s) -
Lee I.Hung,
Huang RayLing,
Chen ChiTing,
Chen HsiaoChuan,
Hsu WenChi,
Lu MeiKuang
Publication year - 2002
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2002.tb11110.x
Subject(s) - mycelium , polysaccharide , mannose , galactose , chemistry , biochemistry , microbiology and biotechnology , biology , botany
Polysaccharides were extracted from fruiting bodies and cultured mycelia from five Antrodia camphorata strains. Polysaccharide profiles of the five strains, as determined by high‐performance anion‐exchange chromatography, showed varying yields and composition of neutral sugars. A. camphorata fruiting bodies also had different polysaccharide patterns compared to the cultured mycelium. Analysis of 26‐day‐old mycelia showed that the neutral sugars galactose, glucose, mannose, and galactosamine were predominant. All mycelia polysaccharide preparations exhibited anti‐hepatitis B virus activity. Polysaccharides from strain B86 at a concentration of 50 μg ml −1 showed the highest level of anti‐hepatitis B surface antigen effect, which was higher than α‐interferon at a dosage of 1000 U ml −1 . Only strains B86 and 35398 had substantial anti‐hepatitis B e antigen activities. None of the polysaccharides exhibited cytotoxic effects.