Open AccessThe flavonoid galangin inhibits the L1 metallo‐β‐lactamase from Stenotrophomonas maltophilia
Author(s) -
Denny Brian J,
Lambert Peter A,
West Patrick W.J.
Publication year - 2002
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2002.tb11054.x
Subject(s) - galangin , stenotrophomonas maltophilia , flavonoid , enzyme , chemistry , quercetin , stenotrophomonas , biochemistry , microbiology and biotechnology , biology , bacteria , kaempferol , antioxidant , gene , 16s ribosomal rna , pseudomonas aeruginosa , genetics
The flavonoid galangin inhibits the partially purified metallo‐β‐lactamase from Stenotrophomonas maltophilia . The effect was not reversed by the addition of ZnCl 2 suggesting that the inhibitory effect is not related to metal chelation. The flavonoid quercetin also has some inhibitory effect against the enzyme. Using the crystal structure of the enzyme, a molecular modelling study predicts a possible orientation of galangin at the active site of the enzyme.