Open AccessAminoguanidine renders inducible nitric oxide synthase knockout mice more susceptible to Salmonella typhimurium infection
Author(s) -
Zhou Xin,
Potoka Douglas A.,
Boyle Patricia,
Nadler Evan P.,
McGinnis Kathleen,
Ford Henri R.
Publication year - 2002
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2002.tb10992.x
Subject(s) - salmonella , nitric oxide synthase , microbiology and biotechnology , in vivo , salmonella infection , nitric oxide , knockout mouse , in vitro , biology , host (biology) , bacteria , chemistry , biochemistry , gene , genetics , endocrinology
Aminoguanidine (AG), a nitric oxide synthase (NOS) inhibitor, has been widely used to study the role of inducible NOS (iNOS) in host defense against infections caused by various pathogens including Salmonella typhimurium . iNOS has been reported to play an important role in host defense against S. typhimurium infection both in vitro and in vivo. In this report we show those AG treatment lead to weight loss in both wild‐type and iNOS knockout mice, and rendered them more susceptible to Salmonella infection. These results suggest that AG may have side effects other than the inhibition of iNOS, and that data obtained from studies using AG should be interpreted with caution.