Open AccessThe Escherichia coli ftsK1 mutation attenuates the induction of σ S ‐dependent genes upon transition to stationary phase
Author(s) -
Diez Alfredo A.,
Tunlid Anders,
Nyström Thomas
Publication year - 2002
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2002.tb10980.x
Subject(s) - rpos , regulon , sigma factor , mutant , gene , biology , mutation , genetics , microbiology and biotechnology , promoter , gene expression
A mutation in the cell division gene ftsK causes super‐induction of σ 70 ‐dependent stress defense genes, such as uspA , during entry of cells into stationary phase. In contrast, we report here that stationary phase induction of σ S ‐dependent genes, uspB and cfa , is attenuated and that σ S accumulates at a lower rate in ftsK1 cells. Ectopic overexpression of rpoS restored induction of the rpoS regulon in the ftsK mutant, as did a deletion in the recA gene. Thus, a mutation in the cell division gene, ftsK , uncouples the otherwise coordinated induction of σ S ‐dependent genes and the universal stress response gene, uspA , during entry into stationary phase.