Open AccessProtein kinases and protein phosphatases in prokaryotes: a genomic perspective
Author(s) -
Kennelly Peter J
Publication year - 2002
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2002.tb10978.x
Subject(s) - phosphatase , biology , dephosphorylation , phylogenetic tree , protein phosphorylation , kinase , protein domain , genome , phylogenetics , computational biology , function (biology) , phosphorylation , structural genomics , genomics , sh3 domain , genetics , evolutionary biology , protein kinase a , protein structure , biochemistry , gene , proto oncogene tyrosine protein kinase src
For many years, the regulation of protein structure and function by phosphorylation and dephosphorylation was considered a relatively recent invention that arose independently in each phylogenetic domain. Over time, however, incidents of apparent domain trespass involving the presence of ‘eukaryotic’ protein kinases or protein phosphatases in prokaryotic organisms were reported with increasing frequency. Today, genomics has provided the means to examine the phylogenetic distribution of ‘eukaryotic’ protein kinases and protein phosphatases in a comprehensive and systematic manner. The results of these genome searches challenge previous conceptions concerning the origins and evolution of this versatile regulatory mechanism.