Open AccessChloride channel antagonists perturb growth and morphology of Neurospora crassa
Author(s) -
Hanke Guy T,
Northrop Frederick D,
Devine Gary R,
Bothwell John H.F.,
Davies Julia M
Publication year - 2001
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2001.tb10763.x
Subject(s) - neurospora crassa , niflumic acid , chloride channel , chemistry , biochemistry , biology , gene , mutant
The chloride channel antagonists anthracene‐9‐carboxylic acid, ethacrynic acid and niflumic acid were found to be fungistatic and morphogenic when tested against the ascomycete Neurospora crassa . Potency increased with decreasing pH, suggesting that the protonated forms of the compounds were active. Niflumic acid produced the most pronounced growth aberrations which may reflect an ability to acidify the cytoplasm and block the plasma membrane anion channel of N. crassa .