Open AccessRole played by the response regulator Ris in Bordetella bronchiseptica resistance to macrophage killing
Author(s) -
Zimna Katarzyna,
Medina Eva,
Jungnitz Heidrun,
Guzmán Carlos A.
Publication year - 2001
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2001.tb10753.x
Subject(s) - bordetella bronchiseptica , regulator , bordetella , microbiology and biotechnology , intracellular , mutant , hyperoxia , bacteria , reactive oxygen species , biology , chemistry , oxygen , biochemistry , bordetella pertussis , gene , genetics , organic chemistry
Previous studies suggested that the persistence in eukaryotic cells of a Bordetella bronchiseptica mutant carrying an insertion in the locus encoding the response regulator RisAS is impaired. This suggested that ris ‐dependent products are required for the intracellular survival of bacteria. In this study we demonstrate that ris ‐regulated products play a role in B. bronchiseptica resistance against both phagosomal acidification and reactive oxygen intermediates.