Open AccessCytotoxic T cells and mycobacteria
Author(s) -
Silva Celio L.,
Bonato Vania L.D.,
Lima Karla M.,
CoelhoCastelo Arlete A.M.,
Faccioli Lúcia H.,
Sartori Alexandrina,
Souza Ana O.,
Leão Sylvia C.
Publication year - 2001
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2001.tb10575.x
Subject(s) - cytotoxic t cell , phagocytosis , immune system , mycobacterium tuberculosis , microbiology and biotechnology , biology , immunology , tuberculosis , bacteria , mycobacterium , cytotoxicity , medicine , genetics , in vitro , pathology
How the immune system kills Mycobacterium tuberculosis is still a puzzle. The classical picture of killing due to phagocytosis by activated macrophages may be only partly correct. Based on recent evidence, we express here the view that cytotoxic T lymphocytes also make an important contribution and suggest that DNA vaccines might be a good way to enhance this.