Open AccessProgesterone side‐chain cleavage by Bacillus sphaericus
Author(s) -
Wadhwa Lalita,
Smith Kelvin E
Publication year - 2000
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2000.tb09379.x
Subject(s) - bacillus sphaericus , androstenedione , side chain , bacillales , cleavage (geology) , bacillaceae , chemistry , microbiology and biotechnology , biochemistry , stereochemistry , biology , bacteria , organic chemistry , hormone , bacillus subtilis , genetics , paleontology , fracture (geology) , androgen , polymer
The side‐chain of progesterone was cleaved by Bacillus sphaericus to produce two C‐19 keto androstene steroids. The structures of these metabolites were androstenedione and 1‐dehydroandrostenedione. High concentrations of glucose in the culture medium inhibited conversion of progesterone to these two metabolites.