Open AccessEffect of the adhesive antibiotic TA on adhesion and initial growth of E. coli on silicone rubber
Author(s) -
Simhi Eliahu,
Mei Henry C.,
Ron Eliora Z.,
Rosenberg Eugene,
Busscher Henk J.
Publication year - 2000
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2000.tb09365.x
Subject(s) - biofilm , adhesion , antibiotics , silicone rubber , microbiology and biotechnology , adhesive , silicone , urinary system , bacteria , escherichia coli , bacterial growth , chemistry , medicine , biology , materials science , composite material , biochemistry , genetics , layer (electronics) , gene
Catheter‐associated urinary tract infection is the most common nosocomial infection, and contributes to patient morbidity and mortality. We investigated the effect that the TA adhesive antibiotic had on adhesion and initial growth in urine of Escherichia coli on silicone rubber. The TA antibiotic had reduced adhesion, and inhibited initial growth of the bacteria on the surface. Since adhesion and initial growth on the surface are an essential part of biofilm formation and subsequent infection, we speculate that the TA antibiotic coating might decrease the infection rate associated with indwelling urinary catheter.