Open AccessA multidrug efflux transporter in Listeria monocytogenes
Author(s) -
Mata M.T.,
Baquero F.,
PérezDíaz J.C.
Publication year - 2000
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2000.tb09158.x
Subject(s) - major facilitator superfamily , efflux , listeria monocytogenes , ethidium bromide , listeria , microbiology and biotechnology , multiple drug resistance , mutant , cefotaxime , biology , transporter , gene , genetics , drug resistance , bacteria , antibiotics , dna
A chromosomal gene ( mdrL ) was found in Listeria monocytogenes L028, showing a high degree of similarity with multidrug efflux transporters of the major facilitator superfamily (family 2). An allele‐substituted mutant of this gene failed to pump out ethidium bromide and presented lower minimal inhibitory concentrations of macrolides, cefotaxime and heavy metals. This is the first multidrug efflux pump described in Listeria .