Open AccessGenomic diversity among Vibrio cholerae O139 strains isolated in Bangladesh and India between 1992 and 1998
Author(s) -
Faruque Shah M.,
Saha Manujendra N.,
Bag Prasanta K.,
Bhadra Rupak K.,
Bhattacharya S.K.,
Sack R.Bradley,
Takeda Yoshifumi,
Nair G.Balakrish
Publication year - 2000
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2000.tb09027.x
Subject(s) - vibrio cholerae , biology , genotype , genetics , microbiology and biotechnology , genetic diversity , vibrionaceae , strain (injury) , antibiotic resistance , cholera , gene , bacteria , population , demography , anatomy , sociology
In order to assess the extent of genomic diversity among Vibrio cholerae O139 strains, restriction fragment length polymorphisms in two genetic loci, rrn and ctx , were studied. Analysis of 144 strains isolated from different regions of Bangladesh and India between 1992 and 1998 revealed the presence of at least six distinct ribotypes (B‐I through B‐VI) of which three were new ribotypes, and one of these was represented by a nontoxigenic O139 strain. Strains of ribotypes B‐I through B‐V shared 11 different CTX genotypes (A through K). Antimicrobial resistance patterns of the strains varied independently of their ribotypes and CTX genotypes. Results of this study suggest that V. cholerae O139 is undergoing rapid genetic changes leading to the origination of new variants, and temporal changes in antimicrobial resistance patterns may be contributing to the selection of different variants.