Open AccessSeparation of NADH‐fumarate reductase and succinate dehydrogenase activities in Trypanosoma cruzi
Author(s) -
Christmas Patrick B,
Turrens Julio F
Publication year - 2000
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2000.tb08962.x
Subject(s) - fumarate reductase , succinate dehydrogenase , reductase , biochemistry , dehydrogenase , enzyme , chemistry , nadh dehydrogenase , biology , protein subunit , gene
A recent review suggested that the activity of NADH‐fumarate reductase from trypanosomatids could be catalyzed by succinate dehydrogenase working in reverse (Tielens and van Hellemond, Parasitol. Today 14, 265–271, 1999). The results reported in this study demonstrate that the two activities can easily be separated without any loss in either activity, suggesting that fumarate reductase and succinate dehydrogenase are separate enzymes.