Open AccessA colicin‐tolerant Escherichia coli mutant that confers Hfl phenotype carries two mutations in the region coding for the C‐terminal domain of FtsH (HflB)
Author(s) -
Teff Dinah,
Koby Simi,
Shotland Yoram,
Ogura Teru,
Oppenheim Amos B.
Publication year - 2000
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2000.tb08943.x
Subject(s) - colicin , mutant , phenotype , escherichia coli , genetics , biology , coding region , mutation , in vivo , gene
An Escherichia coli mutant, ER437, which was originally isolated for colicin tolerance, was found to carry two amino acid changes in the C‐terminal portion of FtsH (HflB). These mutations were demonstrated to reduce the ability of FtsH to degrade the phage λ CII protein in vivo and in vitro, providing a rationalization for the mutant Hfl phenotype.