Open AccessExpression of urease does not affect the ability of Bordetella bronchiseptica to colonise and persist in the murine respiratory tract
Author(s) -
McMillan David J.,
Medina Eva,
Guzmán Carlos A.,
Walker Mark J.
Publication year - 1999
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1999.tb13752.x
Subject(s) - bordetella bronchiseptica , urease , microbiology and biotechnology , respiratory tract , biology , bacteria , respiratory system , enzyme , biochemistry , anatomy , genetics
To investigate the role played by urease during the Bordetella bronchiseptica infection process, the ability to colonise and persist in the mouse respiratory tract of a urease‐negative B. bronchiseptica BB7865 and a BB7865 derivative constitutively expressing urease was compared with that of the wild‐type strain. The results obtained showed that neither constitutive expression nor abolishment of urease activity had any significant effect on the course of B. bronchiseptica infection. Therefore, under our experimental conditions, urease is not essential for B. bronchiseptica to colonise and persist within the murine host.