Open AccessEffect of Cu,Zn superoxide dismutase disruption mutation on replicative senescence in Saccharomyces cerevisiae
Author(s) -
Barker M.Gordon,
Brimage Lydia J.E,
Smart Katherine A
Publication year - 1999
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1999.tb13732.x
Subject(s) - saccharomyces cerevisiae , superoxide dismutase , sod1 , yeast , biochemistry , mutant , galactose , oxidative stress , chemistry , senescence , mutation , biology , gene , microbiology and biotechnology
The role of oxidative damage in determining the replicative lifespan of Saccharomyces cerevisiae was investigated using a wild‐type haploid laboratory yeast and a Cu,Zn superoxide dismutase ( sod1 ) mutant derivative on glucose, ethanol, glycerol and galactose media. SOD1 expression was necessary to ensure longevity on all carbon sources tested. Whilst carbon source and SOD1 gene expression do influence yeast lifespan, the relationship between the two factors is complex.