Open AccessProteolytic cleavage of the repressor (BlaI) of β‐lactamase synthesis in Staphylococcus aureus
Author(s) -
Lewis Richard A.,
Curnock Stephen P.,
Dyke Keith G.H.
Publication year - 1999
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1999.tb08687.x
Subject(s) - staphylococcus aureus , cleavage (geology) , linker , repressor , chemistry , microbiology and biotechnology , bacteria , biology , biochemistry , gene , genetics , transcription factor , paleontology , fracture (geology) , computer science , operating system
The proteolytic cleavage of BlaI was shown to correlate with β‐lactamase synthesis in Staphylococcus aureus . BlaI was found to be autoregulatory when expressed from the blaZ promoter. Insertion of a 10‐bp linker into the Sna BI site of blaRI resulted in constitutive synthesis of β‐lactamase.