Open AccessCharacterization of a Mycobacterium bovis BCG insertion sequence related to the IS21 family
Author(s) -
Lefèvre Philippe,
Braibant Martine,
Content Jean,
Gilot Philippe
Publication year - 1999
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1999.tb08679.x
Subject(s) - mycobacterium bovis , microbiology and biotechnology , mycobacterium , mycobacterium tuberculosis , biology , tuberculosis , mycobacterium tuberculosis complex , insertion sequence , virology , genome , genetics , bacteria , transposable element , gene , medicine , pathology
The structure and distribution of a Mycobacterium bovis BCG insertion element of the IS21 family were investigated. Several IS21‐like elements found in mycobacterial genomes were separated in four types, following their nucleic acid similarities. The M. bovis BCG IS21 element is highly similar to IS1533 (class I), 70% similar to IS1534 (class II), 52% similar to IS1532 (class III) of Mycobacterium tuberculosis , and 54% similar to both an Mycobacterium avium serovar 2 and an M. avium silvaticum IS (class IV). The M. bovis BCG IS21 element of the class I appears to be present in a single copy in the genome of M. bovis BCG, M. bovis , M. tuberculosis and Mycobacterium africanum and to be absent from all other tested species of the Corynebacteria‐Mycobacteria‐Nocardia group.