Open AccessThe leader sequence of the Escherichia coli lysC gene is involved in the regulation of LysC synthesis
Author(s) -
Patte JeanClaude,
Akrim Mohamed,
Méjean Vincent
Publication year - 1998
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1998.tb13313.x
Subject(s) - escherichia coli , bacillus subtilis , gene , genetics , biology , psychological repression , coding region , lysine , gene expression , amino acid , bacteria
In Escherichia coli and Bacillus subtilis , long leader sequences are found upstream of the lysC coding sequences which encode lysine‐sensitive aspartokinase. Highly conserved regions exist between these sequences. Mutations leading to constitutive expression of the E. coli lysC gene have been localised within these conserved regions, indicating that they participate in the lysine‐mediated repression mechanism of lysC expression.