Open AccessVibrio cholerae O22 might be a putative source of exogenous DNA resulting in the emergence of the new strain of Vibrio cholerae O139
Author(s) -
Dumontier Sandrine,
Berche Patrick
Publication year - 1998
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1998.tb13072.x
Subject(s) - vibrio cholerae , biology , vibrionaceae , gene , el tor , strain (injury) , cholera , microbiology and biotechnology , genetics , bacteria , anatomy
The new epidemic strain O139 of Vibrio cholerae , the etiologic agent of cholera, has probably emerged from the pandemic strain O1 El Tor through a genetic rearrangement involving the horizontal transfer of exogenous O‐antigen‐ and capsule‐encoding genes of unknown origin. In V. cholerae O139, these genes are associated with an insertion sequence designated IS 1358 O139 . In this work, we studied the distribution of seven genes flanking the IS 1358 O139 element in 13 serovars of V. cholerae strains. All these O139 genes and an IS 1358 element designated IS 1358 O22‐1 were only found in V. cholerae O22 with a similar genetic organization. Sequence analysis of a 4.5‐kb fragment containing IS 1358 022‐1 and the adjacent genes revealed that these genes are highly homologous to those of V. cholerae O139. These results suggest that strains of V. cholerae O22 from the environment might have been the source of the exogenous DNA resulting in the emergence of the new epidemic strain O139.