Open AccessLack of protection following immunisation with H. pylori outer membrane vesicles highlights antigenic differences between H. felis and H. pylori
Author(s) -
Keenan Jacqueline I,
Allardyce Randall A,
Bagshaw Philip F
Publication year - 1998
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1998.tb12924.x
Subject(s) - helicobacter pylori , bacterial outer membrane , immunogenicity , gastritis , helicobacter , immune system , antigen , biology , microbiology and biotechnology , immunology , cancer , disease , medicine , gene , escherichia coli , genetics
Helicobacter pylori ‐induced inflammation is associated with the development of gastritis, peptic ulcer disease and gastric cancer in humans. Immunisation against this bacterium would ultimately have a major impact on H. pylori ‐related disease, notably global gastric cancer rates. To date, several potential H. pylori vaccine candidates have been identified. In this study, the Helicobacter felis /murine model was used to assess the immunogenicity of a previously undescribed H. pylori outer membrane vesicle fraction in immune protection.