Open AccessAnthrax lethal toxin‐induced mitogenic response of human T‐cells
Author(s) -
GuidiRontani Chantal,
Duflot Edith,
Mock Michele
Publication year - 1997
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1997.tb12786.x
Subject(s) - bacillus anthracis , toxin , secretion , in vitro , biology , microbiology and biotechnology , t lymphocyte , anthrax toxin , bacteria , biochemistry , recombinant dna , gene , fusion protein , genetics
Bacillus anthracis lethal toxin (PALF) stimulated the proliferation of human peripheral blood T‐cells in vitro. Activation of T‐lymphocytes by PALF required the presence of monocytes and did not result from a collaborative effect between T‐cells and B‐cells. PALF acted directly on monocytes and independently of T‐cells. The monocytes contributed to the proliferation of T‐cells by secretion of mediator(s). The mitogenic activity of the lethal toxin was dependent on its metalloprotease activity.