Open AccessNovel bismuth compounds have in vitro activity against Helicobacter pylori
Author(s) -
Midolo P.D,
Norton A,
Itzstein M,
Lambert J.R
Publication year - 1997
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1997.tb12777.x
Subject(s) - helicobacter pylori , bismuth , antimicrobial , sialic acid , in vitro , chemistry , microbiology and biotechnology , pharmacology , biochemistry , biology , organic chemistry , genetics
The increasing antimicrobial resistance in Helicobacter pylori has led to the search for new therapeutic agents. In this in vitro study, novel compounds combining bismuth with sialic acid inhibitors were investigated for bactericidal activity using time‐kill methodology. The activity of these compounds was compared to bismuth subcitrate against a type strain and a clinical isolate of H. pylori . The compounds tested showed cidal activity which was related to the bismuth component of each drug. These compounds may offer a potential advantage over current bismuth preparations with the sialic acid inhibitor moiety interfering with adhesion of H. pylori to gastric epithelium.