Open AccessMercury induces multiple antibiotic resistance in Escherichia coli through activation of SoxR, a redox‐sensing regulatory protein
Author(s) -
Fuentes Ana M,
AmábileCuevas Carlos F
Publication year - 1997
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1997.tb12671.x
Subject(s) - mercury (programming language) , escherichia coli , intracellular , antibiotics , chemistry , lac operon , reactive oxygen species , superoxide , redox , microbiology and biotechnology , biochemistry , biology , gene , enzyme , inorganic chemistry , computer science , programming language
Sub‐inhibitory mercury concentrations are capable of partially activating SoxR, as shown by the augmented expression of a soxS′::lacZ fusion, and a diminished sensitivity to antibiotics caused by mercury treatment. Mercury may elevate the intracellular concentration of superoxide or perhaps act as a putative metal ligand for SoxR.