Open AccessIn vitro plasmid‐encoded resistance to quinolones
Author(s) -
GómezGómez José M.,
Blázquez Jesús,
Espinosa De Los Monteros Luz E.,
Baquero Marıća R.,
Baquero Fernando,
Martıćnez José L.
Publication year - 1997
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1997.tb12655.x
Subject(s) - quinolone , plasmid , escherichia coli , microbiology and biotechnology , mutant , allele , biology , antibiotics , enterobacteriaceae , in vitro , phenotype , strain (injury) , dna gyrase , genetics , gene , anatomy
The possibility of plasmid‐encoded quinolone resistance is explored in two model systems. In the first, increasing amounts of wild‐type gyrA allele moderately increased minimum inhibitory concentrations to quinolone antibiotics. In the second model, a mutant gyrA allele encoded by a multicopy plasmid produced a quinolone resistance phenotype upon its expression in a quinolone‐susceptible Escherichia coli strain.