Open AccessSuppression of Francisella tularensis growth in the rat by co‐infection with F. novicida
Author(s) -
Cowley Siobhan C,
Myltseva Svetlana V,
Nano Francis E
Publication year - 1997
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1997.tb10465.x
Subject(s) - francisella tularensis , francisella , tularemia , microbiology and biotechnology , biology , in vivo , in vitro , antimicrobial , bacteria , nitric oxide , virology , virulence , biochemistry , gene , endocrinology , genetics
We have previously shown that when cultured in vitro, peritoneal rat macrophages infected with Francisella novicida spontaneously release nitric oxide in sufficient quantities to inhibit bacterial growth. However, it is not known whether F. novicida can have a similar antimicrobial effect in vivo. Here we show that a co‐infection of F. novicida with Francisella tularensis can suppress the number of F. tularensis cells in rat spleens by as much as 100‐fold.